Science and Technology has played an ever increasing role in our society. In fact, forensic science must be seen to act as a “watch Dog” on behalf of the community against all hazards and abuse that may threaten it. Hence the service of a forensic science laboratory can be considered as one of the essential needs of the society. Good forensic science laboratories have been created in different countries of the world for the purpose of processing of physical evidence on search of truth. Realizing the need for a modern forensic science laboratory in Nepal, the Judicial Reform Commission (1983) recommended for the establishment of a well equipped and independent forensic science laboratory in the country. In the wake of this recommendation the National Forensic Science Laboratory was set up and run under the aegis of Nepal Academy of Science and Technology (NAST) from 1986 to 1995. From 1995 to 2000 the laboratory was under the Ministry of Law and Justice as an autonomous organization. As per the decision of Government of Nepal, this laboratory is now running as an autonomous organization under the Ministry of Science and Technology.